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Cis-DDPs well-known nephrotoxicity, indeed, has been proved to be related to his GSH-conjugated compounds that, being metabolized to cysteine S-conjugate by cysteine S-conjugate -lyase activity (highly expressed in renal cells), is mainly responsible for proximal tubule cell damage [114]

doi: 10.1016/j.mehy.2009.10.041

Cancer Res 92 , 915 (2001)

Potential TREM-1 related diagnostics and therapeutics include a) soluble TREM-1, a cleaved form of TREM-1 that is increased during sepsis and thought to be a prognostic indicator of sepsis severity, b) LP17 which is a direct competitive inhibitor to the TREM-1 receptor, and c) a decoy receptor for TREM-1 [283]