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Down Regulation: the number of receptors decreases (by proteolysis) upon exposure to a high concentration of agonist for a very long time (hours), making the cell less responsive to the same agonist or others that work at the same receptor
doi: 10.1056/NEJM199811053391909
There have been numerous studies that examined the molecular mechanism(s) of GCLC transcriptional regulation [13]
doi: 10.1073/pnas.1321232111
