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Pathogenic variants were identified using Genome Analysis Toolkit (GATK) pipelines and classified based on the joint guidelines of ACMG (American College of Medical Genetics and Genomics) and AMP (Association of Molecular Pathology)

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Han R., Liang J., and Zhou B., Glucose Metabolic Dysfunction in Neurodegenerative DiseasesNew Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming, International Journal of Molecular Sciences 22, no

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Oxidative stress and antioxidant markers (vitamins and antioxidant enzymatic activity) were determined in plasma every month

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