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Several substituents were also well tolerated at R 2 , but using a cyclopropylmethyl moiety at R 2 produced the most potent PDE5 inhibitor of the series ( 14 ) with an IC 50 of 0.26 nM
Statin use and the risk of hepatocellular carcinoma: a meta-analysis of observational studies
Results PTM-dependent ligandability profiling in human cells To investigate changes in protein ligandability as a function of phosphorylation status, we aimed to broadly perturb phosphorylation while minimizing potential convoluting proteomic alterations
& Hutter, M
