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The IL4R-targeted (KLAKLAK)2 peptide acted on IL-4R-high and M2-polarized TAMs as well as tumor cells and reduced the proportion of M2-type TAMs in the tumor microenvironment 54

3 Several different parameters in the tumour microenvironment influence the regulation of cancer cell migration and invasion: the presence of hypoxia, chemoattractants, ECM stiffness and a lack of nutrients prompt cancer cells to start searching for a better life