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The most promising derivatives, 2- thiomorpholine 1,1-dioxide (TMS), aminoethylmethylsulfone (AEMS) and N-methyl- thiomorpholine 1,1-dioxide (MTMS), are more potent than other cyclic compounds including TAHS and CAHS

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Romero JI, Hanschmann EM, Gellert M, Eitner S, Holubiec MI, Blanco-Calvo E, Lillig CH, Capani F
When arteries become stiff, the heart has to work much harder to pump blood through the body
