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Our findings might be attributed to boosting the cholesterol total fecal excretion through the bile and inhibiting its absorption in the gut (75)

[Google Scholar] 107.Karim S, Pratibha PK, Kamath S, Bhat GS, Kamath U, Dutta B, et al

The upregulation of IL-1 and TNF- respectively by colchicine and MCC950, however, was a bit surprising, and could possibly be explained by the interplay between these two cytokines in self-regulating each other, although further studies must be conducted to clarify this issue