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Further evidence from antibiotic intervention experiments (Yarandi et al., 2020) shows that ampicillin treatment, which reduces Gram-positive bacteria and enriches Gram-negative bacteria, significantly decreases colonic nNOS enzymatic activity and nitrergic neuron count in mice, impairing colonic motility

Absorption Challenges: Pernicious Anemia and Dietary Factors While some individuals may experience B12 deficiency due to dietary choices, others face challenges in absorbing the vitamin

Because of this, lots of people have mild to moderate vitamin B12 deficiencies due to unbalanced diets or other factors
These predispositions do not determine treatment response absolutely, but they can help contextualize why some individuals report robust energy improvements while others see minimal benefit
