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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

While B12 is usually safe, too much can be harmful

If levels climb high into normal range and symptoms resolve, continue the current protocol

Consult with a healthcare provider: If the results of B12 and folate testing are abnormal, it is important to consult with a healthcare provider who can interpret the results and provide appropriate guidance