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Description
in 2007 provided a comprehensive characterization of exhausted CD8 T cells, defining a common signature that includes upregulation of inhibitory receptors (PD-1, CTLA4, CD244a, and LAG-3), downregulation of nave/memory-related molecules (CD62L, IL-7R, TCF1, and LEF-1), impaired cell cycling, and a substantial reduction in cytokine production

Phase II Trials In a phase II double-blind, randomized, placebo-controlled trial, Jastreboff et al

Ann Oncol (2003) 14 (9):14307

A.van den BergL
