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Methylxanthines and the kidney

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Los transportadores de cationes orgnicos (OCTN) regulan la distribucin tisular y la homeostasis intracelular de L-carnitina y funcionan tanto en su absorcin intestinal como en la reabsorcin renal

Transport of ALCAR across cell membranes, including the blood-brain barrier, is primarily mediated by the organic cation/carnitine transporter 2 (OCTN2, encoded by SLC22A5), a sodium-dependent transporter expressed on the luminal side of endothelial cells [5]