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Consideration of the H 2 O 2 levels in unstressed aerobic cells (50 nM) and in OxyR-activated stressed cells (1 M) argues that millimolar H 2 O 2 concentrations are hugely excessive and will detect oxidation events that are vanishingly rare in nature

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Antioxidants serve a key role in mitigating inflammation-induced oxidative stress by scavenging free radicals and maintaining the body's redox balance

It is worth noting that cellular senescence also plays important beneficial roles in physiological processes such as tissue development, wound healing, and tumor suppression (Suter et al., 2025)