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The risk of significant anemia during HDDCT was minimized using high dose folinic acid (75 mg PO BID) with high dose L-methylfolate (45 mg PO BID) and mean drops in hemoglobin of 1.75 g during the four-day pulse (N = 10
Decreased G6PD activity can trigger hemoglobin denaturation (Heinz body and bite cell in blood smears) and membrane damage (hemolysis) in RBCs
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