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However, a recent study demonstrated that the spread of -syn pathology does not always proceed as expected along the connectome, either anterogradely or retrogradely, through a template-recruitment process reminiscent of that observed in prion diseases (Sorrentino et al., Therapeutic Approaches Targeting -Syn for PD Treatment There is currently no disease-modifying therapies for PD, but medication or surgery can provide palliative treatment directed at controlling symptoms that may substantially improve motor impairments

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J Leukoc Biol 77:598625

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