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Evidence remains largely preclinical, with growing interest in translational applications for aging, metabolic disorders, and neurodegeneration

For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions

LM22A-4 has shown neuroprotective effects in Alzheimer cell culture models, and Dihexa restored learning and memory in rats with scopolamine-induced cognitive impairment

Contraindications & Precautions Neonates and infants: Absolutely do NOT use BAC water for babies