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Description
Indeed, TT genotype individuals have a decline in their MTHFR activity

doi: 10.1080/03602532.2017.1306544

[3] [6] If no reversible cause is found, or when found it cannot be eliminated, lifelong vitamin B 12 administration is usually recommended

Many patients notice an improvement in energy and mental clarity within 2448 hours of a B12 or Lipo-B injection
