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You could argue that with huge dose you might get enough in, but might isnt something I would not want as part of my healthcare if the consequences are permanent disability

CDK9 forms a subunit of the positive transcription elongation factor b (P-TEFb) in partnership with cyclin T, regulating gene transcription through phosphorylating the C-terminus domain (CTD) of RNA polymerase II (Pol II) and stimulating its release from paused phase into transcriptional elongation 15,16,17

One option that can provide permanent or temporary relief from these knots is trigger point injections

It has also been found to decrease the subunits of NMDA receptors NR2A, NR2B in rodents (188190)