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Oncogene 24 , 17491766 (2005)

Bagchi et al found that OPCs are highly bioavailable and provide significantly greater protection against free radical damage than beta carotene and vitamins C and E
The oxidation site at position His343 facilitates the secretion of legumain in ccRCC Given the evidence that activation of HIF2/MCJ leads to excess ROS accumulation, we further investigated whether an oxidation site regulates the processing of legumain under these conditions