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Perianal disease (fistulas, fissures or ulcers near the anus) has been reported to be more frequent in Black, South Asian and Hispanic people

Alternatively, it can be mixed with water or juice before consumption

Some senolytics, such as FOXO4-DRI, require peptide-based delivery, which is complex and may limit clinical application.58 Blood-brain barrier penetration is another challenge, making it difficult for senolytics to target neurodegenerative diseases effectively.121 Long-Term Consequences and Need for Repeated Treatment: The long-term effects of senolytic therapy remain unclear, as eliminating senescent cells could disrupt tissue homeostasis
