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10.1038/s43018-020-00121-4

Common genetic variants, called MTHFR C677T and A1298C, affect how the enzyme works and impact the availability of methyl groups.[ref] Genetic variants are variations in the DNA sequence that can influence the function of a gene or the protein it encodes

The polyol pathway leads to the conversion of glucose to sorbitol and further to fructose, thus reducing the availability of cofactors such as NADPH needed for the glutathione peroxidaseglutathione reductase system, rendering the cell more vulnerable to reactive oxygen species (ROS), and therefore reinforcing oxidative stress [39][40]

doi:10.1021/acs.accounts.0c00832 40