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Moreover, a macrophage phagocytosis study revealed that the BsNb-ncAA exhibited improved capability to inhibit immune evasion and demonstrated stronger biological activity than the BsNb-fusion

doi: 10.1186/s12905-021-01187-7

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Opening at 2 mg weekly rather than 4 mg markedly softens early GI effects, and any higher weekly dose simply calls for more than one vial or a split across two sites