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Parallelly, folic acid and vitamin B6 serve as pivotal cofactors for synthesis of serotonin from tryptophan

The results revealed significant differences in the levels of ethanol dehydrogenase (ADH) and phenylethanolamine N-methyltransferase (PNMT) between groups (Lee et al., 2017)
[Google Scholar] 72.Hosseinzade A., Sadeghi O., Biregani A.N., Soukhtehzari S., Brandt G.S., Esmaillzadeh A

Other in vitro studies reveal that TNF- could reduce melanocyte-stimulating hormones receptor (MSH-R) binding activity, MC1R expression, and the expression of a melanosomal protein gp87, promoters of melanogenesis 141 , 142