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Acute inhibition of the TCA cycle (TCAi) in mouse kidney epithelial cells results in increased glutathione synthesis and impaired proline and aspartate synthesis (Figure 2)

M., et al

In some tissues, such as that of liver, heart, and kidney, mitochondrial glycerol-3-phosphate dehydrogenase (GPD2) is present in very low amounts, and the malate-aspartate shuttle is the dominant pathway for aerobic oxidation of cytosolic NADH

The cost ranges from $20 to $100 per injection, depending on provider, location, and whether it includes consultation
