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Furthermore, mutant p53 has been shown to inhibit the activity of the antioxidant transcription factor Nrf2, which may lead to reduced expression of SLC7A11, a component of the x c cystine-glutamate antiporter, and thus decreased levels of GSH 39

In another way, thyroid hormones, ROS, or both, may modulate the expression of the enzyme DNMT-1, responsible for DNA methylation, causing the silencing or overexpression of immunoregulatory genes and contributing to the pathogenesis of Graves disease

PubMed , The FASEB Journal , vol

Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA) Brain Res