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All protocol-level guidance is based on published data and preclinical evidence cited inline
An evaluation in 78 PD patients and 32 controls showed considerably lower CSF t- -Syn levels in PD patients (Mollenhauer et al., 2019)

These are designed for comfort and ease of use

In addition, arterial pulsation facilitates the exit of ISF solutes in the opposite direction to blood flow along cerebral arteries 21
