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In addition, the upregulation of the MAPK pathway by viruses seems to be involved with the downregulation of IFN production and the consequent impairment of the cellular innate immune response, benefiting viral replication (107, 108)

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In conjunction with a delayed accumulation and nuclear translocation of ATM-phosphorylated HIF1, PKM2 co-activates HIF1 96 to instigate a metabolic program favoring lipid biogenesis

J Lab Cin Med 70(1):158169