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Interestingly, the same beta-sheet is reinforced (less solvent-exposed) in CENP-A nucleosomes as an allosteric effect of CENP-C binding (30)
The metabolism of INH inside pathogens, i.e., bacteria, mediated by bacterial KatG enzyme leads to the activation of the INH, which is critical for antimicrobial potency of INH
No approach has demonstrated significant and sustainable reductions in HLA antibody prior to transplant, and patients with elevated PRA continue to be at higher risk for rejection and reduced survival (64)
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