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The energy gradient is also considered at each stage of minimization, which is further used as additional information to calculate the new vector directions for the minimization procedure

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The motivation for investigating synthetic lethal targets was that there may be other drugs that act on multiple L

Findings from in vitro and in vivo studies have indicated curcumin can protect neuronal cells against mitochondrial pathology in a wide range of neurodegenerative-inducing stressors such as cerebral ischemia, and exposure to neurotoxic compounds such as methamphetamine, alcohol, rotenone, hydrogen peroxide, glutamate, interferon- and aluminium [150,151,152,153,154,155]