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Gastrointestinal Research Models: Analysis of biological pathways associated with gastrointestinal tissue function and cellular protection mechanisms

Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

Free Radic Biol Med 120:414424 Shaw P, Chattopadhyay A (2020) Nrf2ARE signaling in cellular protection: mechanism of action and the regulatory mechanisms