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Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome

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This dynamic communication between the mitochondria and the nucleus establishes a finely regulated signaling network, enabling the cell to respond to fluctuating metabolic or stress pressures and adjust gene expression to regulate the cellular senescence process [161]

However, this may be associative rather than causal as another study found that bone marrow fat content was primarily affected by age and BMI, more so than CKD, as measured by the IDEAL-IQ sequence of MRI (544)