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Here, Cui and colleagues discuss the mechanisms that lead to leptin and ghrelin resistance, and how they might be exploited as targets for the management and treatment of obesity.

Colton Center for Autoimmune Diseases (Tel Aviv University) Israeli Ministry of Innovation, Science and Technology Israeli Innovation Authority (IIA) Longevity and Health Research Center at Tel Aviv University Marian Gertner Institute for Medical Nano systems Yoran Institute for Advanced PhD Students in Personalized Medicine

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