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It exerts protective effects primarily through sGC-cGMP-PKG signaling and via S-nitrosylation of target proteins during I/R injury 38,39
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Rheumatic Disease Clin North Am 23:757778 Hoekstra M, Haagsma C, Neef C, Proost J, Knuif A, van de Laar M (2004) Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis
