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f, g, h) Correlation of glutamate labelling in the primary cell lines with response to Imatinib (R 2 = .55, F(1, 9) = 11.0, p = 0.009) (f) , Gefitinib (R 2 = .38, F(1, 9) = 5.46, p = 0.0443) (g) and AZD2014 (R 2 = .55, F(1, 9) = 10.83, p = 0.0094) (h) treatment

A study using a three-dimensional tumour sphere model combined with CRISPR-Cas9 screening reported that Nrf2 overactivation was essential for lung tumour proliferation and survival, whereas silencing of Nrf2 predisposed spherical cells to ferroptosis, which was also consistent with clinical observations [77]

Neither SOD nor catalase activities were significantly affected by GliSODin ingestion (baseline values GliSODin vs

Vanderlelie and Perkins [7] evaluated the oxidative stress at the end of the reproduction in rats in placental and liver tissues, but they do not describe the alteration of GP activity, resulting from the coordination of tissue GSH reductase and GSSG peroxidase enzyme activities in both selenium deficiency and L-NAME oral administration