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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

Additionally, this aim will be partially delivered, since the assay lacked the sensitivity required for measuring CMV-Hb in single erythrocytes and SE-MALDI could not be used to enhance throughput (see aim 2 and 3)
Effects on cellular NAD+ and SAM pools in vitro
