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Recent research suggests that reduced glutathione may be an even more effective antioxidant than vitamins C and E, and it is considered the master antioxidant. GSH protects tissues by neutralizing free radicals and improves the immune system by promoting antigen presentation and stimulating CD8 cells

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and (3) tune dose, timing, and delivery (mitochondria-, ER-, or plasma-membrane-targeted) to preserve physiological H 2 O 2 signaling while attenuating pathological microdomains