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A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a cascade of intracellular components that mediate its effects, plays a major role in the regulation of skeletal muscle growth

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Glutathione peroxidase-1 (gpx-1) is an anti-oxidant enzyme that may protect lungs from such damage

This underscores that metabolites are not merely passive by-products but active biochemical regulators of genome instability
