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Understanding this mechanism matters because it explains why most GI side effects are dose-dependent, temporary, and manageable through titration strategies
Knowing this helps us understand how and why hormone replacement may or may not be ideal, and how problems can occur
FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage (Kalantar et al., 2019a
