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Additionally, frataxin deficiency in dorsal root ganglia disrupts iron homeostasis and impairs Nrf2 activation and its downstream redox signaling pathways, thereby promoting ferroptotic injury (391)

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The antioxidant components of the MDsuch as polyphenols, vitamins C and A, -carotene, folate, and dietary fibermay enhance reproductive tract antioxidant status, counteract oxidative stress, and protect against reactive oxygen species-related damage, thereby supporting fertility

doi: 10.1074/jbc.M116.727479