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Furthermore, this disruptive feature might be facilitated by the aggregation-promoting prion-like feature of FUS/TLS 52

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Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk

Furthermore, NFIL3 itself is regulated by the REV-ERB/ROR feedback loop, highlighting the interconnected nature of these regulatory mechanisms within the CR system (Gachon et al., 2004) (Figure 1)
