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Enhancing M2 macrophage activity could help mitigate chronic inflammation and ferroptosis responses, creating a more favorable environment for repair

Resistance to tamoxifen with persisting sensitivity to estrogen: possible mediation by excessive antiestrogen binding site activity

A clinical phase 2 trial is currently evaluating this compound as a single agent and in combination with endocrine therapy in patients with HR+, HER2 breast cancer and other cancer types

Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE