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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems

The relative numbers of fibers with an EdU + myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively

Both decreases and increases in reduced glutathione (GSH) and glutathione disulfide (GSSG) levels were reported in fibroblasts undergoing senescence, including replicative senescence (RS), oncogene-induced senescence (OIS), and therapy-induced senescence (TIS) (Quijano et al., 2012

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