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Since the clock components of the liver were not altered, the authors speculated that the tumor may not function as a classical zeitgeber, but rather that it acts on the liver by rewiring circadian metabolic control, thereby dictating the pathophysiological dimension of a distal tissue 128

(3) Restoring the adrenal GRK2-2-AR-catecholamine axis to normalize sympathetic tone (Rengo et al., 2010)

The pool of 2HG reflects epigenetic and redox remodeling in IDH-mutant tumors, whereas elevated glycine is associated with increased nucleotide demand and proliferative activity

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