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J Gastroenterol Hepatol 21(Suppl 3):S22S25

The DNA coding sequence was synthesized by GeneArt (Thermo Fisher) and cloned into vector pcDNA3.1 (Addgene)

In a prospective study of lung cancer patients receiving chemoimmunotherapy, CBM588 supplementation significantly improved OS and ORR compared to controls ( Bifidobacterium breve abundance was identified as a biomarker predicting improved outcomes in NSCLC patients undergoing anti-PD-1 therapy combined with chemotherapy ( Post hoc analyses of two prospective Japanese cohorts ( n = 40 and n = 42) showed that baseline abundance of Faecalibacterium prausnitzii 1.2% was an independent prognostic factor for longer OS (HR 0.48, 95% CI 0.260.89), irrespective of CBM588 administration ( F