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Neurobiol Aging 26:7790 Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA (2006) Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimers disease

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It tends to help most when it's part of a broader plan, which is why we prefer to discuss it in the context of your overall goals
