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Out of bounds labeling PEG-fusion non-specifically fuses closely apposed axons regardless of modality or original connectivity, potentially resulting in incorrect connections between proximal and distal axons (Bittner et al., 2022)

Though not dangerous, these symptoms can be uncomfortable and may persist with continued high-dose usage

This effect was investigated in the cuprizone induced demyelination model of C57/BL6 mice CNS

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