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Perhaps the best studied to these is 20-HETE, which has been linked with vasoconstriction and the regulation of myogenic tone

Differential diagnosis: Hepatocellular necrosis resulting from direct toxicity may have a diffuse or lobular distribution but also may be accompanied by infarction

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The following subsections describe this process stepwise, starting with the exposure pathways to highlight their role in shaping the fate and toxicity of PM-associated substances, and then linking the particlexenobiotic interactions, systemic distribution, and pathophysiological effects