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10.1016/j.ica.2019.05.021 85 KhalidQ.AhmadM.MinhasM
Hooda Z,, Langburt D, Ries S, Antonoff M, Mehran R, Rajaram R, Rice DC , Swisher S, Vaporciyan A, Walsh G, Mitchell K, Ferri L, Hofstetter W
Also, when AG490 (100 M) was used to block the JAK2-STAT3 pathway, a significant decrease was observed in the expression of JAK2, p-JAK2, STAT3, p-STAT3, and GSTP1 24 h after treating the LoVo cells (Figure 4F)
Moreover, Hspa1a knockdown significantly increased the protein levels of GRP78, PERK, and DDIT3 in KK1 cells, indicating activation of ER stress
