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reported that a high level of TMAO increased Smad3 phosphorylation, which promoted renal interstitial fibrosis and dysfunction

also known as decarboxylated S -adenosylmethionine, dcAdoMet or dcSAM), which retains the methyl group usually involved in SAM methyltransferase activity

Zhang Y, Brady M, Smith S

Vanyai et al, 2015)