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It has various effects like antiamyloid aggregation

7.3.1 Gut microbiota and its impact on BBB integrity The gut microbiota can influence BBB integrity via several mechanisms, including the modulation of the immune system and the production of metabolites that affect the brain

Welp A, Manz B, Peschke E (2010) Development and validation of a high throughput direct radioimmunoassay for the quantitative determination of serum and plasma melatonin (N-acetyl-5-methoxytryptamine) in mice

A predictive eco-metabolomic framework for AQflavonoid systems should combine (i) multifactorial experimental designs that manipulate at least two interacting abiotic drivers, (ii) high-resolution metabolomic profiling across tissues and developmental stages, and (iii) integrative analytical approaches linking metabolite data to physiological performance and fitness proxies