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Chronic neuroinflammation and synmediated cellular stress further contribute to behavioral and cognitive impairments, underscoring the multifaceted and systemwide nature of PD pathophysiology [13, 14, 15, 16, 17, 24]

Additionally, alanine is reported to be significantly increased with metformin monotherapy and combined with sulfonylurea, and branched-chain amino acids (valine, leucine, and isoleucine) are increased with metformin therapy (t Hart et al., 2018b)

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References : J Jang, HG Hur, MJ Sadowsky, MN Byappanahalli, T-Yan, S Ishii - Environmental Escherichia coli: ecology and public health implications-a review - J Appl Microbiol